Rapoport Natalya
Department of Bioengineering, University of Utah, 36 South Wasatch Drive, Room, 3100, Salt Lake City, UT, 84112, USA.
Adv Exp Med Biol. 2016;880:221-41. doi: 10.1007/978-3-319-22536-4_13.
The interaction of nanoparticles with directed energy is a novel application in targeted drug delivery. This chapter focuses on perfluorocarbon nanoemulsions, whose action in drug delivery depends on the ultrasound-triggered phase shift from liquid to gaseous state. These nanoemulsions have great potential for unloading encapsulated drugs at a desired time and location in the body in response to directed ultrasound. In addition, they actively alter their nano-environment for enhancing drug transport through various biological barriers to sites of action, which significantly enhances therapeutic outcome.
纳米颗粒与定向能量的相互作用是靶向药物递送中的一种新型应用。本章重点关注全氟碳纳米乳剂，其在药物递送中的作用取决于超声触发的从液态到气态的相转变。这些纳米乳剂具有巨大潜力，可根据定向超声在体内所需的时间和位置释放封装的药物。此外，它们能主动改变其纳米环境，以增强药物通过各种生物屏障到达作用部位的运输，从而显著提高治疗效果。
