用于癌症药物输送的相移、刺激响应型全氟碳纳米液滴。
Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer.
机构信息
Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.
出版信息
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Sep-Oct;4(5):492-510. doi: 10.1002/wnan.1176. Epub 2012 Jun 22.
Abstract
This review focuses on phase-shift perfluorocarbon nanoemulsions whose action depends on an ultrasound-triggered phase shift from a liquid to gas state. For drug-loaded perfluorocarbon nanoemulsions, microbubbles are formed under the action of tumor-directed ultrasound and drug is released locally into tumor volume in this process. This review covers in detail mechanisms involved in the droplet-to-bubble transition as well as mechanisms of ultrasound-mediated drug delivery.
摘要
这篇综述专注于相移全氟碳纳米乳剂，其作用取决于超声触发的从液态到气态的相移。对于载药的全氟碳纳米乳剂，在肿瘤靶向超声的作用下形成微泡，在此过程中药物局部释放到肿瘤体积中。本综述详细介绍了液滴到气泡转变的机制以及超声介导药物传递的机制。
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