Chao W Y, Huang C C
Department of Otolaryngology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Acta Otolaryngol. 1989 Mar-Apr;107(3-4):249-53. doi: 10.3109/00016488909127505.
Filaggrin, a histidine-rich protein, was located immunohistochemically in human middle ear cholesteatoma by specific antibody. It was found to be localized in the cytoplasm of the granular layer cells and cornified layer. The pattern of distribution is similar to that of epidermis. Filaggrin is a major component of keratohyalin which is a distinct component of the differentiating epidermal cells. Thus the presence of filaggrin in cholesteatoma suggests epidermal characteristics of the cholesteatoma.
丝聚合蛋白是一种富含组氨酸的蛋白质，通过特异性抗体在免疫组织化学上定位于人中耳胆脂瘤中。发现它定位于颗粒层细胞和角质化层的细胞质中。其分布模式与表皮相似。丝聚合蛋白是角蛋白透明颗粒的主要成分，角蛋白透明颗粒是分化中的表皮细胞的一种独特成分。因此，胆脂瘤中丝聚合蛋白的存在表明胆脂瘤具有表皮特征。
