Marx Wolfgang, McKavanagh Daniel, McCarthy Alexandra L, Bird Robert, Ried Karin, Chan Alexandre, Isenring Liz
Health Sciences & Medicine, Bond University, Gold Coast, Queensland, Australia.
Division of Cancer Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
PLoS One. 2015 Oct 21;10(10):e0141119. doi: 10.1371/journal.pone.0141119. eCollection 2015.
The potential effect of ginger on platelet aggregation is a widely-cited concern both within the published literature and to clinicians; however, there has been no systematic appraisal of the evidence to date.
Using the PRISMA guidelines, we systematically reviewed the results of clinical and observational trials regarding the effect of ginger on platelet aggregation in adults compared to either placebo or baseline data. Studies included in this review stipulated the independent variable was a ginger preparation or isolated ginger compound, and used measures of platelet aggregation as the primary outcome.
Ten studies were included, comprising eight clinical trials and two observational studies. Of the eight clinical trials, four reported that ginger reduced platelet aggregation, while the remaining four reported no effect. The two observational studies also reported mixed findings.
Many of the studies appraised for this review had moderate risks of bias. Methodology varied considerably between studies, notably the timeframe studied, dose of ginger used, and the characteristics of subjects recruited (e.g. healthy vs. patients with chronic diseases).
The evidence that ginger affects platelet aggregation and coagulation is equivocal and further study is needed to definitively address this question.
生姜对血小板聚集的潜在影响在已发表的文献中以及临床医生中都是一个被广泛提及的关注点；然而，迄今为止尚未对相关证据进行系统评估。
我们依据PRISMA指南，系统回顾了关于生姜与安慰剂或基线数据相比对成年人血小板聚集影响的临床和观察性试验结果。本综述纳入的研究规定自变量为生姜制剂或分离出的生姜化合物，并将血小板聚集测量作为主要结局。
共纳入10项研究，包括8项临床试验和2项观察性研究。在8项临床试验中，4项报告生姜可降低血小板聚集，其余4项报告无效果。2项观察性研究也报告了不同的结果。
本综述评估的许多研究存在中度偏倚风险。研究之间的方法差异很大，特别是研究的时间范围、使用的生姜剂量以及招募对象的特征（如健康人与慢性病患者）。
生姜影响血小板聚集和凝血的证据尚不明确，需要进一步研究来明确解决这个问题。
