[感染在年龄相关性黄斑变性发病机制中的作用]
[Role of infection in the pathogenesis of age-related macular degeneration].
作者信息
Slepova O S, Eremeeva E A, Ryabina M V, Sorozhkina E S
机构信息
Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
出版信息
Vestn Oftalmol. 2015 Jul-Aug;131(4):56-59. doi: 10.17116/oftalma2015131456-59.
AIM
to study the role of infectious agents in the development and progression of AMD by means of serodiagnostic assay for a complex of ophthalmotropic and opportunistic infections.
MATERIAL AND METHODS
The study enrolled 61 patients (23 men, 38 women) aged 43-68 years and diagnosed in accordance with AREDS classification of AMD. Serodiagnostic tests were performed for 11 infections with the purpose of identifying antigen-specific antibodies in the serum.
RESULTS
Activation markers of one or several infections were detected in most of the patients with AMD.
CONCLUSION
Herpes viruses (HSV1 and CMV) along with some opportunistic pathogens are important factors in the pathogenesis of AMD, thereby, specific treatment should be performed in these patients.
目的
通过对一系列亲眼性和机会性感染进行血清学诊断检测，研究感染因子在年龄相关性黄斑变性（AMD）发生和发展中的作用。
材料与方法
该研究纳入了61例年龄在43 - 68岁之间的患者（23名男性，38名女性），这些患者均根据AMD的年龄相关性眼病研究（AREDS）分类进行诊断。为检测11种感染进行了血清学诊断测试，目的是识别血清中的抗原特异性抗体。
结果
在大多数AMD患者中检测到一种或几种感染的激活标志物。
结论
疱疹病毒（HSV1和CMV）以及一些机会性病原体是AMD发病机制中的重要因素，因此，应对这些患者进行特异性治疗。
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