Ayala-Peña Victoria Belen
Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca CP8000, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires CP8000, Argentina.
Viruses. 2025 Jul 29;17(8):1056. doi: 10.3390/v17081056.
Herpes simplex virus type 1 (HSV-1) is associated with eye infections. Specifically, the acute consequences of eye infections have been extensively studied. This review gathers information on possible collateral damage caused by HSV-1 in the retina, such as age-related macular degeneration (AMD), a neurodegenerative disease. The synthesis and accumulation of Amyloid-β peptide (Aβ) is a key hallmark in these types of pathologies. AMD is a disease of multifactorial origin, and viral infections play an important role in its development. It is known that once this virus has entered the eye, it can infect adjacent cells, thus having the ability to infect almost any cell type with great tropism. In the retina, retinal pigment epithelial (RPE) cells are primarily involved in AMD. This work reviews publications that show that RPE can produce Aβ, and once they are infected by HSV-1, the release is promoted. Also, all the information available in the literature that explains how these events may be interconnected has been compiled. This information is valuable when planning new treatments for multifactorial neurodegenerative diseases.
1型单纯疱疹病毒（HSV-1）与眼部感染有关。具体而言，眼部感染的急性后果已得到广泛研究。本综述收集了有关HSV-1在视网膜中可能造成的附带损害的信息，例如年龄相关性黄斑变性（AMD），一种神经退行性疾病。淀粉样β肽（Aβ）的合成和积累是这类病症的关键标志。AMD是一种多因素起源的疾病，病毒感染在其发展过程中起着重要作用。已知一旦这种病毒进入眼睛，它就可以感染相邻细胞，因此有能力以很强的嗜性感染几乎任何细胞类型。在视网膜中，视网膜色素上皮（RPE）细胞主要参与AMD。这项工作回顾了表明RPE可以产生Aβ的出版物，并且一旦它们被HSV-1感染，Aβ的释放就会被促进。此外，还汇编了文献中所有解释这些事件可能如何相互关联的可用信息。这些信息在规划多因素神经退行性疾病的新治疗方法时很有价值。
