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[放射化学实验室课程中低放射性68Ge/68Ga发生器的制造与应用]

[Manufacture and Utilization of a Low-level Radioactive 68Ge/68Ga Generator in a Radiochemistry Laboratory Course].

作者信息

Washiyama Kohshin, Amano Ryohei, Nozaki Tadashi, Ogawa Koji, Nagatsu Kotaro, Sakama Minoru, Ido Tatuo, Yamaguchi Hiroshi

机构信息

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.

出版信息

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2015 Oct;71(10):983-93. doi: 10.6009/jjrt.2015_JSRT_71.10.983.

Abstract

The low-level radioactivity of a (68)Ge/(68)Ga generator is a suitable tool for measuring radioactive growth and decay after (68)Ga milking due to their desirable nuclear decay properties, such as the EC decay of (68)Ge with no γ-ray emission andthe β(+) decay of (68)Ga with a weak γ-ray emission. To experience andund erstandrad ioactive equilibrium during a university laboratory course, we surveyedandtestedthe production of a small amount of (68)Ge and set up educational programs to manufacture a (68)Ge/(68)Ga generator for measuring the growth andd ecay of (68)Ga. The irradiation of natGa with 25 μA of a 30 MeV proton beam from a cyclotron for 4 h yields ca. 111 MBq of (68)Ge, which was sufficient to supply to several universities. For use as the adsorbent of the generator column, particles of hydrated tin (VI) oxide were prepared from precipitated tin hydroxide gel. Repeated elution of (68)Ga from the handmade (68)Ge/(68)Ga generator gave constant amounts of (68)Ga with acceptable breakthrough of (68)Ge. The feedback from the student's experience with the (68)Ge/(68)Ga generator was evaluatedby annual questionnaire surveys, which were given to all students taking the course every year from 2012 to 2014. It has been made clear that more than half of the students were interested in the (68)Ge/(68)Ga generator program, andthis interest increasedfrom 54.9%in 2012 to 78.6%in 2014. A low-level radioactive (68)Ge/(68)Ga generator is thus expectedto be a suitable experimental tool for demonstrating the phenomenon of radioactivity to students in an intriguing way.

摘要

(68)Ge/(68)Ga发生器的低水平放射性是一种合适的工具,用于测量(68)Ga淋洗后的放射性生长和衰变,这归因于它们理想的核衰变特性,例如(68)Ge的电子俘获衰变且无γ射线发射,以及(68)Ga的β(+)衰变且γ射线发射较弱。为了在大学实验室课程中体验和理解放射性平衡,我们调查并测试了少量(68)Ge的生产,并设立了教育项目来制造用于测量(68)Ga生长和衰变的(68)Ge/(68)Ga发生器。用回旋加速器产生的25 μA、30 MeV质子束辐照天然镓4小时可产生约111 MBq的(68)Ge,这足以供应给几所大学。作为发生器柱的吸附剂,从沉淀的氢氧化锡凝胶制备了水合氧化锡(VI)颗粒。从手工制作的(68)Ge/(68)Ga发生器中反复洗脱(68)Ga,得到了恒定数量的(68)Ga,且(68)Ge的穿透量可接受。通过年度问卷调查对学生使用(68)Ge/(68)Ga发生器的体验反馈进行了评估,问卷发放给了2012年至2014年每年参加该课程的所有学生。结果表明,超过一半的学生对(68)Ge/(68)Ga发生器项目感兴趣,且这种兴趣从2012年的54.9%增加到了2014年的78.6%。因此,低水平放射性(68)Ge/(68)Ga发生器有望成为以有趣的方式向学生展示放射性现象的合适实验工具。

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