自然杀伤T细胞发育过程中对TCF1和LEF1的细胞自主需求。
Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells.
作者信息
Berga-Bolaños Rosa, Zhu Wandi S, Steinke Farrah C, Xue Hai-Hui, Sen Jyoti Misra
机构信息
Immune Cells and Inflammation Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States.
Department of Microbiology, Interdisciplinary Immunology Graduate Program, University of Iowa, Iowa City, IA 52242, United States.
出版信息
Mol Immunol. 2015 Dec;68(2 Pt B):484-9. doi: 10.1016/j.molimm.2015.09.017. Epub 2015 Oct 17.
Abstract
Natural killer T (NKT) cells develop from common CD4(+) CD8(+) thymocyte precursors. Transcriptional programs that regulate the development of NKT cells in the thymus development remain to be fully delineated. Here, we demonstrate a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of NKT cells. Conditional deletion of TCF1 alone results in a substantial reduction in NKT cells. The remaining NKT cells are eliminated when TCF1 and LEF1 are both deleted. These data reveal an essential role for TCF1 and LEF1 in development of NKT cells.
摘要
自然杀伤T（NKT）细胞由常见的CD4(+) CD8(+)胸腺细胞前体发育而来。调节胸腺发育中NKT细胞发育的转录程序仍有待全面阐明。在此，我们证明转录因子TCF1和LEF1对所有NKT细胞亚群的发育具有细胞内在需求。单独条件性缺失TCF1会导致NKT细胞大量减少。当TCF1和LEF1都被缺失时，剩余的NKT细胞会被消除。这些数据揭示了TCF1和LEF1在NKT细胞发育中的重要作用。
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本文引用的文献
1
T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development.
PLoS One. 2014 Dec 23;9(12):e115803. doi: 10.1371/journal.pone.0115803. eCollection 2014.
2
TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells.
Nat Immunol. 2014 Jul;15(7):646-656. doi: 10.1038/ni.2897. Epub 2014 May 18.
3
The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.
Immunity. 2012 Nov 16;37(5):813-26. doi: 10.1016/j.immuni.2012.08.009. Epub 2012 Oct 25.
4
Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors.
Dev Biol. 2012 Aug 1;368(1):44-53. doi: 10.1016/j.ydbio.2012.05.012. Epub 2012 May 26.
5
Control of early stages in invariant natural killer T-cell development.
Immunology. 2011 Sep;134(1):1-7. doi: 10.1111/j.1365-2567.2011.03463.x. Epub 2011 Jun 30.
6
Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes.
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6211-6. doi: 10.1073/pnas.1014304108. Epub 2011 Mar 28.
7
The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.
Nat Immunol. 2010 May;11(5):435-41. doi: 10.1038/ni.1865. Epub 2010 Apr 11.
8
An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells.
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9
Raising the NKT cell family.
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10
Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.
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