针对与2型糖尿病相关的胰岛淀粉样多肽的特异性抗体。

Antibodies specific for the pancreatic islet amyloid polypeptide associated with type 2 diabetes mellitus.

作者信息

Glenner G G, Ceja F, Mehlhaff P

机构信息

University of California, San Diego 92093.

出版信息

Biochem Biophys Res Commun. 1989 Mar 15;159(2):402-7. doi: 10.1016/0006-291x(89)90005-3.

DOI:10.1016/0006-291x(89)90005-3

PMID:2649092

Abstract

Antibodies raised to a lysine solubilized peptide composed of residues 20-29 of the pancreatic islet amyloid polypeptide react selectively and specifically with this polypeptide and with islet amyloid deposits in Type 2 diabetes mellitus. These antibodies may prove useful in studies employing radioimmunoassay of body fluids and islet cell cultures in order to define if a pathogenic relationship exists between the islet amyloid polypeptide and Type 2 diabetes mellitus.

摘要

针对由胰岛淀粉样多肽20 - 29位残基组成的赖氨酸增溶肽产生的抗体，能选择性且特异性地与该多肽以及2型糖尿病患者的胰岛淀粉样沉积物发生反应。这些抗体可能在采用体液放射免疫测定和胰岛细胞培养的研究中发挥作用，以确定胰岛淀粉样多肽与2型糖尿病之间是否存在致病关系。