Igarashi T, Oka K, Miyamoto T
Division of Hospital, National Institute of Radiological Sciences, Chiba City, Japan.
Br J Cancer. 1989 Mar;59(3):356-60. doi: 10.1038/bjc.1989.71.
Direct transplantation of non-Hodgkin's malignant lymphoma into athymic nude mice was successfully achieved after whole-body irradiation (5 Gy). Twenty-seven per cent (6/22) of transplanted lymphomas were established as nude mouse lines. The successful lines were derived solely from the patients with diffuse lymphoma who showed advanced clinical stage, high LDH value, large mass and poor prognosis. The histological, immunophenotypic and chromosomal characteristics of the nude mouse lines were compared with those of the original lymphomas, and the proliferative characteristics of the lines were examined. The transplanted lymphomas substantially retained the characteristics of the original lymphomas, and could be useful in biological, oncological and therapeutic studies of human malignant lymphoma.
在全身照射（5 Gy）后，成功地将非霍奇金恶性淋巴瘤直接移植到无胸腺裸鼠体内。27%（6/22）的移植淋巴瘤被建立为裸鼠系。成功的裸鼠系仅来源于弥漫性淋巴瘤患者，这些患者临床分期较晚、乳酸脱氢酶（LDH）值高、肿块大且预后差。将裸鼠系的组织学、免疫表型和染色体特征与原始淋巴瘤的特征进行比较，并检测裸鼠系的增殖特征。移植的淋巴瘤基本保留了原始淋巴瘤的特征，可用于人类恶性淋巴瘤的生物学、肿瘤学和治疗研究。
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