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代谢组学标准协调组织(COSMOS):促进代谢组学数据的集成访问。

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access.

作者信息

Salek Reza M, Neumann Steffen, Schober Daniel, Hummel Jan, Billiau Kenny, Kopka Joachim, Correa Elon, Reijmers Theo, Rosato Antonio, Tenori Leonardo, Turano Paola, Marin Silvia, Deborde Catherine, Jacob Daniel, Rolin Dominique, Dartigues Benjamin, Conesa Pablo, Haug Kenneth, Rocca-Serra Philippe, O'Hagan Steve, Hao Jie, van Vliet Michael, Sysi-Aho Marko, Ludwig Christian, Bouwman Jildau, Cascante Marta, Ebbels Timothy, Griffin Julian L, Moing Annick, Nikolski Macha, Oresic Matej, Sansone Susanna-Assunta, Viant Mark R, Goodacre Royston, Günther Ulrich L, Hankemeier Thomas, Luchinat Claudio, Walther Dirk, Steinbeck Christoph

机构信息

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD UK ; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA UK.

Department of Stress and Developmental Biology, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.

出版信息

Metabolomics. 2015;11(6):1587-1597. doi: 10.1007/s11306-015-0810-y. Epub 2015 May 26.

Abstract

Metabolomics has become a crucial phenotyping technique in a range of research fields including medicine, the life sciences, biotechnology and the environmental sciences. This necessitates the transfer of experimental information between research groups, as well as potentially to publishers and funders. After the initial efforts of the metabolomics standards initiative, minimum reporting standards were proposed which included the concepts for metabolomics databases. Built by the community, standards and infrastructure for metabolomics are still needed to allow storage, exchange, comparison and re-utilization of metabolomics data. The Framework Programme 7 EU Initiative 'coordination of standards in metabolomics' (COSMOS) is developing a robust data infrastructure and exchange standards for metabolomics data and metadata. This is to support workflows for a broad range of metabolomics applications within the European metabolomics community and the wider metabolomics and biomedical communities' participation. Here we announce our concepts and efforts asking for re-engagement of the metabolomics community, academics and industry, journal publishers, software and hardware vendors, as well as those interested in standardisation worldwide (addressing missing metabolomics ontologies, complex-metadata capturing and XML based open source data exchange format), to join and work towards updating and implementing metabolomics standards.

摘要

代谢组学已成为包括医学、生命科学、生物技术和环境科学在内的一系列研究领域中的关键表型分析技术。这就需要在研究团队之间,以及可能向出版商和资助者传递实验信息。在代谢组学标准倡议的初步努力之后,提出了最低报告标准,其中包括代谢组学数据库的概念。由社区构建的代谢组学标准和基础设施仍然是必要的,以便存储、交换、比较和重新利用代谢组学数据。欧盟第七框架计划“代谢组学标准协调”(COSMOS)倡议正在为代谢组学数据和元数据开发强大的数据基础设施和交换标准。这是为了支持欧洲代谢组学社区内广泛的代谢组学应用工作流程,以及更广泛的代谢组学和生物医学社区的参与。在此,我们公布我们的概念和努力,呼吁代谢组学社区、学术界和产业界、期刊出版商、软件和硬件供应商,以及全球范围内对标准化感兴趣的人士(解决代谢组学本体缺失、复杂元数据捕获和基于XML的开源数据交换格式问题)重新参与进来,共同努力更新和实施代谢组学标准。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/4605977/0a4e8df3ec12/11306_2015_810_Fig1_HTML.jpg

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