通过硅羧酸将¹¹CO₂快速高效地转化为¹¹CO：在钯介导的羰基化反应中的应用
Rapid and Efficient Conversion of (11) CO2 to (11) CO through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations.
作者信息
Nordeman Patrik, Friis Stig D, Andersen Thomas L, Audrain Hélène, Larhed Mats, Skrydstrup Troels, Antoni Gunnar
机构信息
Platform for Preclinical PET, Department of Medicinal Chemistry, Uppsala University, P.O Box 574, 751 23, Uppsala (Sweden), Fax: (+46) 184714474.
Carbon Dioxide Activation Center (CADIAC), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 86196199.
出版信息
Chemistry. 2015 Dec 1;21(49):17601-4. doi: 10.1002/chem.201503262. Epub 2015 Oct 23.
Herein, we present a new rapid, efficient, and low-cost radiosynthetic protocol for the conversion of (11) CO2 to (11) CO and its subsequent application in Pd-mediated reactions of importance for PET applications. This room-temperature methodology, using readily available chemical reagents, is carried out in simple glass vials, thus eliminating the need for expensive and specialized high-temperature equipment to access (11) CO. With this fast and near-quantitative conversion of (11) CO2 into (11) CO, aryl and heteroaryl iodides were easily converted into a broad selection of biologically active amides in radiochemical yields ranging from 29-84 %.
在此，我们展示了一种新的快速、高效且低成本的放射性合成方案，用于将(^{11}CO_2)转化为(^{11}CO)，以及其随后在对正电子发射断层扫描（PET）应用具有重要意义的钯介导反应中的应用。这种室温方法使用易于获得的化学试剂，在简单的玻璃瓶中进行，从而无需使用昂贵且专门的高温设备来制备(^{11}CO)。通过将(^{11}CO_2)快速且近乎定量地转化为(^{11}CO)，芳基和杂芳基碘化物能够轻松转化为多种生物活性酰胺，其放射化学产率范围为29 - 84%。
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