通过氟化物活化的乙硅烷物种将[C]CO瞬间转化为[C]CO 。
Instantaneous Conversion of [ C]CO to [ C]CO via Fluoride-Activated Disilane Species.
作者信息
Taddei Carlotta, Bongarzone Salvatore, Gee Antony D
机构信息
Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas' Hospital, London, Lambeth Palace Road, SE1 7EH, United Kingdom.
出版信息
Chemistry. 2017 Jun 7;23(32):7682-7685. doi: 10.1002/chem.201701661. Epub 2017 May 17.
The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([ C]CO) from cyclotron-produced carbon-11 carbon dioxide ([ C]CO ) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74 % conversion of [ C]CO to [ C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl- C]N-benzylbenzamide was successfully synthesized from produced [ C]CO in up to 74 % radiochemical yield (RCY) and >99 % radiochemical purity (RCP) in ≤10 min from end of [ C]CO delivery.
描述了一种快速且新颖的方法，该方法通过氟化物活化的乙硅烷物种介导，从回旋加速器产生的碳 - 11二氧化碳（[¹¹C]CO₂）生成碳 - 11一氧化碳（[¹¹C]CO）。该方法使用市售试剂、易于获得的实验室设备和温和的反应条件（室温），可将[¹¹C]CO₂高达74%转化为[¹¹C]CO。作为实用性的证明，从产生的[¹¹C]CO中成功合成了放射化学纯的[羰基 - ¹¹C]N - 苄基苯甲酰胺，放射化学产率（RCY）高达74%，放射化学纯度（RCP）>99%，在[¹¹C]CO输送结束后≤10分钟内即可完成。
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