非肥胖型糖尿病（NOD）小鼠中的胰岛素自身抗体。
Insulin autoantibodies in non-obese diabetic (NOD) mice.
作者信息
Michel C, Boitard C, Bach J F
机构信息
Service d'Immunologie Clinique, INSERM U 25, CNRS UA 122 Hôpital Necker, Paris, France.
出版信息
Clin Exp Immunol. 1989 Mar;75(3):457-60.
Abstract
Anti-insulin autoantibodies were detected in NOD mice using ELISA. The antibodies were detected as early as at 5 weeks of age, long before onset of clinically overt diabetes, especially in diabetes-prone female mice. The anti-insulin specificity was verified by passage on affinity chromatography insulin columns and demonstration that the anti-insulin activity was located on the F(ab')2 region of the immunoglobulins. The presence of anti-insulin antibodies in prediabetic NOD mice provides a unique possibility for studying their significance and their eventual pathogenic role in the development of insulin-dependent diabetes.
摘要
使用酶联免疫吸附测定法（ELISA）在非肥胖糖尿病（NOD）小鼠中检测到抗胰岛素自身抗体。这些抗体早在5周龄时就被检测到，远在临床明显糖尿病发作之前，尤其是在易患糖尿病的雌性小鼠中。通过在亲和层析胰岛素柱上进行传代，并证明抗胰岛素活性位于免疫球蛋白的F(ab')2区域，验证了抗胰岛素特异性。糖尿病前期NOD小鼠中抗胰岛素抗体的存在为研究它们在胰岛素依赖型糖尿病发展中的意义及其最终致病作用提供了独特的可能性。
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