Gonzalez Maria Carolina, Villar Maria Eugenia, Igaz Lionel M, Viola Haydée, Medina Jorge H
Laboratorio de Memoria, IBCN, UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.
Grupo de Neurociencias de Sistemas, IFIBIO Houssay, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.
Neurobiol Learn Mem. 2015 Dec;126:1-6. doi: 10.1016/j.nlm.2015.10.007. Epub 2015 Oct 19.
The medial prefrontal cortex (mPFC) is known for its role in decision making and memory processing, including the participation in the formation of extinction memories. However, little is known regarding its contribution to aversive memory consolidation. Here we demonstrate that neural activity and protein synthesis are required in the dorsal mPFC for memory formation of a conditioned taste aversion (CTA) task and that this region is involved in the retrieval of recent and remote long-term CTA memory. In addition, both NMDA receptor and CaMKII activity in dorsal mPFC are needed for CTA memory consolidation, highlighting the complexity of mPFC functions.
内侧前额叶皮质（mPFC）因其在决策和记忆处理中的作用而闻名，包括参与消退记忆的形成。然而，关于其对厌恶记忆巩固的贡献却知之甚少。在这里，我们证明背侧mPFC中的神经活动和蛋白质合成对于条件性味觉厌恶（CTA）任务的记忆形成是必需的，并且该区域参与近期和远期长期CTA记忆的提取。此外，背侧mPFC中的NMDA受体和CaMKII活性对于CTA记忆巩固都是必需的，这突出了mPFC功能的复杂性。
