卵形丝孢酵母引起的皮下感染：一例报告并文献复习
Subcutaneous Infection Associated with Trichosporon ovoides: A Case Report and Review of Literature.
作者信息
Mohd Tap Ratna, Sabaratnam Parameswari, Ramli Nur Yasmin, Hashim Rohaidah, Mohd Fuat Abd Razak, Ng Pey Peng, Khairam Husna, Ahmad Norazah
机构信息
Bacteriology Unit, Infectious Diseases Research Center, Institute for Medical Research, Jalan Pahang, 50588, Kuala Lumpur, Malaysia.
Microbiology Unit, Pathology Department, Sultanah Bahiyah Hospital, Alor Setar, Kedah, Malaysia.
出版信息
Mycopathologia. 2016 Apr;181(3-4):285-90. doi: 10.1007/s11046-015-9958-2. Epub 2015 Oct 22.
Trichosporon species are opportunistic yeasts which can cause infections, especially in immunocompromised patients. This is a report of Trichosporon ovoides that caused subcutaneous infection in a patient with underlying ischemic heart disease. The identification of fungal isolate was confirmed by PCR sequencing of ITS and large subunit regions in rRNA gene. In vitro susceptibility study showed that the isolate was susceptible to amphotericin B, fluconazole and voriconazole, and resistant to caspofungin, anidulafungin and itraconazole. The lesion improved after treatment with oral fluconazole and topical miconazole.
毛孢子菌属是机会性酵母，可引起感染，尤其是在免疫功能低下的患者中。本文报告了1例卵形毛孢子菌引起的皮下感染病例，该患者患有缺血性心脏病。通过对rRNA基因ITS和大亚基区域进行PCR测序，确认了分离出的真菌。体外药敏研究表明，该分离株对两性霉素B、氟康唑和伏立康唑敏感，对卡泊芬净、阿尼芬净和伊曲康唑耐药。口服氟康唑和外用咪康唑治疗后，皮损有所改善。
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