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首例两例与多重耐药酵母费雷多尼亚卡尔根斯菌相关的真菌感染病例

First Two Cases of Fungal Infections Associated with Multi-drug Resistant Yeast, Fereydounia khargensis.

作者信息

Tap Ratna Mohd, Ramli Nur Yasmin, Sabaratnam Parameswari, Hashim Rohaidah, Bakri Ahmed Rafezzan Ahmed, Bee Lim Bee, Ginsapu Stephanie Jane, Ahmad Rahimah, Razak Mohd Fuat Abd, Ahmad Norazah

机构信息

Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia.

Microbiology Unit, Pathology Department, Queen Elizabeth Hospital, 88200, Kota Kinabalu, Sabah, Malaysia.

出版信息

Mycopathologia. 2016 Aug;181(7-8):531-7. doi: 10.1007/s11046-016-0002-y. Epub 2016 Mar 24.

DOI:10.1007/s11046-016-0002-y
PMID:27010640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4937094/
Abstract

The number of new fungal pathogens is increasing due to growing population of immunocompromised patients and advanced identification techniques. Fereydounia khargensis is a yeast and was first described in 2014 from environmental samples. As far as we know, this is the first report of human infections associated with F. khargensis. The yeasts were isolated from blood of a HIV-positive patient and pleural fluid of chronic renal failure patient. Amplification and sequencing of the internal transcribed spacer and the large subunit regions confirmed the identity of the isolates. Both isolates showed multi-drug resistance to antifungal agents tested.

摘要

由于免疫功能低下患者数量的增加和先进的鉴定技术，新型真菌病原体的数量正在上升。哈尔根费雷杜尼亚酵母是一种酵母菌，于2014年首次从环境样本中被描述。据我们所知，这是首例与哈尔根费雷杜尼亚酵母相关的人类感染报告。这些酵母菌分别从一名HIV阳性患者的血液和一名慢性肾衰竭患者的胸腔积液中分离得到。对内部转录间隔区和大亚基区域进行扩增和测序，证实了分离株的身份。两种分离株对所测试的抗真菌药物均表现出多重耐药性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/325f/4937094/e17a42b85603/11046_2016_2_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/325f/4937094/e695d9c2b430/11046_2016_2_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/325f/4937094/61f500ff5944/11046_2016_2_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/325f/4937094/e17a42b85603/11046_2016_2_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/325f/4937094/e695d9c2b430/11046_2016_2_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/325f/4937094/61f500ff5944/11046_2016_2_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/325f/4937094/e17a42b85603/11046_2016_2_Fig3_HTML.jpg

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