磁共振引导药物递送
Magnetic Resonance-Guided Drug Delivery.
作者信息
Mikhail Andrew S, Partanen Ari, Yarmolenko Pavel, Venkatesan Aradhana M, Wood Bradford J
机构信息
Center for Interventional Oncology, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Center for Interventional Oncology, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA; Philips Healthcare, 3000 Minuteman Road, Andover, MA 01810, USA.
出版信息
Magn Reson Imaging Clin N Am. 2015 Nov;23(4):643-55. doi: 10.1016/j.mric.2015.05.012. Epub 2015 Jul 9.
The use of clinical imaging modalities for the guidance of targeted drug delivery systems, known as image-guided drug delivery (IGDD), has emerged as a promising strategy for enhancing antitumor efficacy. MR imaging is particularly well suited for IGDD applications because of its ability to acquire images and quantitative measurements with high spatiotemporal resolution. The goal of IGDD strategies is to improve treatment outcomes by facilitating planning, real-time guidance, and personalization of pharmacologic interventions. This article reviews basic principles of targeted drug delivery and highlights the current status, emerging applications, and future paradigms of MR-guided drug delivery.
将临床成像模态用于靶向给药系统的引导，即所谓的图像引导药物递送（IGDD），已成为一种增强抗肿瘤疗效的有前景的策略。磁共振成像（MR成像）特别适合IGDD应用，因为它能够以高时空分辨率获取图像和进行定量测量。IGDD策略的目标是通过促进药理干预的规划、实时引导和个性化来改善治疗效果。本文综述了靶向给药的基本原理，并重点介绍了MR引导药物递送的现状、新兴应用和未来模式。
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