巴西南里奥格兰德州新生儿脐带血清中的多氯联苯。
Polychlorinated biphenyls in umbilical cord serum of newborns from Rio Grande do Sul state, Brazil.
作者信息
Mohr Susana, Sifuentes dos Santos Joice, Schwanz Thiago Guilherme, Wagner Roger, Mozzaquatro Joseane Oliveira, Lorenzoni Alessandra Scherer, Costabeber Ijoni Hilda
机构信息
Departamento de Tecnologia e Ciência dos Alimentos, Centro de Ciências Rurais, Universidade Federal de Santa Maria, CEP 97105-900 Santa Maria, RS, Brazil.
Mestrado em Ciência e Tecnologia de Leite e Derivados, Universidade Norte do Paraná, Rua Marselha, 591, CEP 86041-140 Londrina, PR, Brazil.
出版信息
Clin Chim Acta. 2015 Dec 7;451(Pt B):323-8. doi: 10.1016/j.cca.2015.10.019. Epub 2015 Oct 22.
BACKGROUND
Polychlorinated biphenyls (PCBs) are food-chain contaminants that have been shown to contaminate foods worldwide. The newborn are exposed to these organochlorine compounds across the placenta and through breastfeeding. They are proven to be carcinogenic and may contribute to congenital malformation etiology.
METHODS
This study examined levels of five PCB congeners (28, 52, 138, 153 and 180) in umbilical cord serum samples from 148 newborns from Rio Grande do Sul state, Brazil. Serum concentrations of PCBs were analyzed by gas chromatography with electron capture detection and mass spectrometry.
RESULTS
Levels of ∑PCBs ranged from 0.35 to 55.17 ng/ml in umbilical cord serum positive samples, and PCB 138 was the most prevalent congener. Only 7.4% of samples presented no PCB congener.
CONCLUSIONS
Some PCB congener cord serum levels were related to the locale of the mothers' residence, smoking and drinking habits, fruit consumption, and congenital malformation.
背景
多氯联苯（PCBs）是食物链污染物，已被证明在全球范围内污染食物。新生儿通过胎盘和母乳喂养接触这些有机氯化合物。它们被证实具有致癌性，并可能导致先天性畸形病因。
方法
本研究检测了来自巴西南里奥格兰德州148名新生儿脐带血清样本中五种多氯联苯同系物（28、52、138、153和180）的水平。采用气相色谱-电子捕获检测和质谱法分析血清中多氯联苯的浓度。
结果
脐带血清阳性样本中总多氯联苯水平在0.35至55.17 ng/ml之间，多氯联苯138是最普遍的同系物。只有7.4%的样本未检测到多氯联苯同系物。
结论
某些多氯联苯同系物的脐带血清水平与母亲的居住地点、吸烟和饮酒习惯、水果摄入量以及先天性畸形有关。
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