Wändell Per, Carlsson Axel C, Ljunggren Gunnar
Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Academic Primary Healthcare Centre, Stockholm County Council, Huddinge, Sweden.
Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Prev Med. 2015 Dec;81:387-91. doi: 10.1016/j.ypmed.2015.10.003. Epub 2015 Oct 21.
Study of prevalence of gout with concomitant diseases.
Study population included all living persons in Stockholm County, Sweden, on January 1st 2013 (N=2,124,959). A diagnosis of gout was identified during 2013-2014, with information of diabetes mellitus and insulin resistance, hypertension, chronic heart failure, chronic kidney disease, alcohol abuse, and malignancies. Age-adjusted odds ratios (ORs) with 95% confidence intervals (95% CI) for women and men with gout, using individuals without gout as referents, were calculated.
Age-adjusted odds of co-morbidities among individuals with gout vs. those without gout were: diabetes mellitus and insulin resistance 3.97 (95% CI 3.65-4.31) in women and 1.88 (95% CI 1.78-1.99) in men; hypertension 4.02 (95% CI 3.69-4.37) in women and 3.21 (95% CI 3.06-3.37) in men; chronic heart failure 4.72 (95% CI 4.31-5.19) in women and 2.84 (95% CI 2.66-3.04) in men; chronic kidney disease 2.08 (95% CI 1.50-2.87) in women and 2.39 (95% CI 2.15-2.66) in men; alcohol abuse 8.98 (95% CI 8.15-9.80) in women and 4.38 (95% CI 4.10-4.69) in men; and malignancies 1.32 (95% CI 1.17-1.48) in women and 1.13 (95% CI 1.06-1.21) men.
Gout is a warning sign for concomitant diseases, e.g. alcoholism, diabetes, cardiovascular diseases, and cancer. KEY MESSAGES.
研究痛风合并其他疾病的患病率。
研究人群包括2013年1月1日瑞典斯德哥尔摩县所有在世居民（N = 2,124,959）。在2013 - 2014年期间确定痛风诊断，并获取糖尿病和胰岛素抵抗、高血压、慢性心力衰竭、慢性肾脏病、酒精滥用及恶性肿瘤的相关信息。以无痛风者为对照，计算痛风患者中女性和男性的年龄调整优势比（OR）及95%置信区间（95%CI）。
痛风患者与无痛风者相比，合并症的年龄调整优势比为：女性糖尿病和胰岛素抵抗为3.97（95%CI 3.65 - 4.31），男性为1.88（95%CI 1.78 - 1.99）；女性高血压为4.02（95%CI 3.69 - 4.37），男性为3.21（95%CI 3.06 - 3.37）；女性慢性心力衰竭为4.72（95%CI 4.31 - 5.19），男性为2.84（95%CI 2.66 - 3.04）；女性慢性肾脏病为2.08（95%CI 1.50 - 2.87），男性为2.39（95%CI 2.15 - 2.66）；女性酒精滥用为8.98（95%CI 8.15 - 9.80），男性为4.38（95%CI 4.10 - 4.69）；女性恶性肿瘤为1.32（95%CI 1.17 - 1.48），男性为1.13（95%CI 1.06 - 1.21）。
痛风是合并其他疾病的警示信号，如酗酒、糖尿病、心血管疾病和癌症。关键信息。
