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病毒、干性、胚胎发生与癌症：向治疗抵抗性恶性肿瘤新型癌靶标的分子定义迈出的奇迹般飞跃？

Viruses, stemness, embryogenesis, and cancer: a miracle leap toward molecular definition of novel oncotargets for therapy-resistant malignant tumors?

作者信息

Glinsky Gennadi V

机构信息

Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.

出版信息

Oncoscience. 2015 Sep 12;2(9):751-4. doi: 10.18632/oncoscience.237. eCollection 2015.

DOI:10.18632/oncoscience.237
PMID:26501080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4606008/
Abstract

Recent breakthrough studies documented consistent activation of specific endogenous retroviruses in human embryonic stem cells and preimplantation human embryos and demonstrated the essential role of the sustained retroviral activities for maintenance of pluripotency and embryonic stem cell identity. Present analysis has led to the hypothesis that activation of the human stem cell-associated retroviruses (SCARs), namely LTR7/HERVH and LTR5_Hs/HERVK, is likely associated with the emergence of clinically lethal therapy resistant death-from-cancer phenotypes in a sub-set of cancer patients diagnosed with different types of malignant tumors.

摘要

最近的突破性研究记录了人类胚胎干细胞和植入前人类胚胎中特定内源性逆转录病毒的持续激活，并证明了持续的逆转录病毒活性对于维持多能性和胚胎干细胞特性的重要作用。目前的分析得出一个假设，即人类干细胞相关逆转录病毒（SCARs），即LTR7/HERVH和LTR5_Hs/HERVK的激活，可能与一部分被诊断患有不同类型恶性肿瘤的癌症患者中出现临床上致命的治疗抵抗性癌症死亡表型有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec0/4606008/bc8462426299/oncoscience-02-0751-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec0/4606008/bc8462426299/oncoscience-02-0751-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec0/4606008/bc8462426299/oncoscience-02-0751-g001.jpg

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本文引用的文献

1
Transposable Elements and DNA Methylation Create in Embryonic Stem Cells Human-Specific Regulatory Sequences Associated with Distal Enhancers and Noncoding RNAs.转座元件与DNA甲基化在胚胎干细胞中产生与远端增强子和非编码RNA相关的人类特异性调控序列。
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Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells.人类植入前胚胎和多能细胞中的内源性逆转录病毒激活
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Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells.
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转座元件和远端增强子对胚胎干细胞中人类特异性间期染色质结构特征进化的贡献。
Chromosome Res. 2018 Mar;26(1-2):61-84. doi: 10.1007/s10577-018-9571-6. Epub 2018 Jan 15.
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Mechanistically Distinct Pathways of Divergent Regulatory DNA Creation Contribute to Evolution of Human-Specific Genomic Regulatory Networks Driving Phenotypic Divergence of Homo sapiens.不同调控DNA产生的机制不同的途径有助于驱动智人表型分化的人类特异性基因组调控网络的进化。
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不同类别的内源性逆转录病毒元件的动态转录标记了特定人群的早期人类胚胎细胞。
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Expression and Functional Role of Reprogramming-Related Long Noncoding RNA (lincRNA-ROR) in Glioma.重编程相关长链非编码RNA（lincRNA-ROR）在胶质瘤中的表达及功能作用
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Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.灵长类特异性内源性逆转录病毒驱动的转录定义了类似原始状态的干细胞。
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lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6.长链非编码RNA-RoR和miR-145通过靶向ARF6调控三阴性乳腺癌的侵袭。
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Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance.哺乳动物干细胞的深度转录组分析支持逆转录转座子在多能性维持中的调节作用。
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