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正电子发射断层扫描（PET）在前列腺癌成像中的新前景：一位物理学家的观点。

New prospects for PET in prostate cancer imaging: a physicist's viewpoint.

作者信息

Conti Maurizio

机构信息

Siemens Healthcare Molecular Imaging, 810 Innovation Drive, Knoxville, TN, 37932, USA.

出版信息

EJNMMI Phys. 2014 Dec;1(1):11. doi: 10.1186/2197-7364-1-11. Epub 2014 Sep 9.

DOI:10.1186/2197-7364-1-11
PMID:26501453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6890878/
Abstract

Prostate cancer is one of the most common forms of cancer among men. Early diagnosis, correct staging, accurate detection of metastasis, and monitoring of the therapy are the key tasks that could greatly benefit from medical imaging. After a review of the main developments in the field of positron emission tomography (PET) tracers for prostate cancer, the impact of improved PET instrumentation with good spatial resolution and high sensitivity is discussed, together with the latest development in PET technology: lutetium oxy-ortho-silicate (LSO) and lutetium-yttrium oxy-ortho-silicate (LYSO) scintillators, resolution recovery, and time-of-flight reconstruction. New directions and multiple approaches in PET instrumentation for prostate cancer are presented and discussed. In particular, improved hardware and noise suppressing reconstruction algorithms allow for higher detectability of small lesions and better spatial resolution in PET/computerized tomography (CT) and PET/magnetic resonance (MR). This can be beneficial for guiding biopsy and surgery and for accurate therapy monitoring.

摘要

前列腺癌是男性中最常见的癌症形式之一。早期诊断、正确分期、准确检测转移以及监测治疗是关键任务，医学成像能使其大大受益。在回顾了前列腺癌正电子发射断层扫描（PET）示踪剂领域的主要进展后，讨论了具有良好空间分辨率和高灵敏度的改进型PET仪器的影响，以及PET技术的最新发展：正硅酸镥（LSO）和钇正硅酸镥（LYSO）闪烁体、分辨率恢复和飞行时间重建。介绍并讨论了前列腺癌PET仪器的新方向和多种方法。特别是，改进的硬件和噪声抑制重建算法可提高PET/计算机断层扫描（CT）和PET/磁共振（MR）中对小病变的检测能力以及更好的空间分辨率。这有助于指导活检和手术以及进行准确的治疗监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d5/6890878/a39803265968/40658_2014_Article_9002_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d5/6890878/580aa14a58d5/40658_2014_Article_9002_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d5/6890878/5401d16ab18e/40658_2014_Article_9002_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d5/6890878/a39803265968/40658_2014_Article_9002_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d5/6890878/580aa14a58d5/40658_2014_Article_9002_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d5/6890878/5401d16ab18e/40658_2014_Article_9002_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d5/6890878/a39803265968/40658_2014_Article_9002_Fig3_HTML.jpg

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