氧雄龙的神经再生作用：一例报告
Neuroregenerative Effect of Oxandrolone: A Case Report.
作者信息
Bianchi Vittorio, Marbini Adriana
机构信息
Laboratory of Physiology of Exercise and Human Performance, Stella Maris Clinical Center, Falciano, San Marino.
Department of Neuroscience, University of Parma, Parma, Italy.
出版信息
Am J Case Rep. 2015 Oct 27;16:763-7. doi: 10.12659/ajcr.893901.
BACKGROUND
Anabolic steroids have the clinical effect of increasing protein synthesis in muscle and other tissues. The brain and spinal cord neurons have gonadal steroid receptors and various studies have shown at structural and molecular levels that androgenic steroids have a significant trophic effect on the brain and spinal cord.
CASE REPORT
We evaluated the effect of Oxandrolone (an FDA-approved anabolic steroid) at the dose of 20 mg/day for 3 months added to concomitant exercise strength training 3 times a week in a patient affected by a demyelinating disease, Charcot-Marie-Toot 1 (CMT1). After the treatment, an increase in muscular strength and walking capacity was observed. Muscle biopsy revealed a significant increase of type grouping of muscle fibers, an expression of regeneration and reinnervation processes.
CONCLUSIONS
Data ensuing from this single case-report suggest that anabolic androgenic steroids have a potential neuroregenerative effect, with an inherent improvement in neuromuscular efficiency through an increased myelin synthesis at peripheral nervous system site.
背景
合成代谢类固醇具有增加肌肉和其他组织中蛋白质合成的临床效果。脑和脊髓神经元具有性腺类固醇受体，并且各种研究已在结构和分子水平上表明，雄激素类固醇对脑和脊髓具有显著的营养作用。
病例报告
我们评估了氧雄龙（一种经美国食品药品监督管理局批准的合成代谢类固醇）以20毫克/天的剂量添加到每周3次的伴随运动力量训练中，对一名患有脱髓鞘疾病——夏科-马里-图思病1型（CMT1）患者的影响。治疗后，观察到肌肉力量和行走能力有所增加。肌肉活检显示肌纤维类型分组显著增加，这是再生和再支配过程的一种表现。
结论
该单病例报告得出的数据表明，合成代谢雄激素类固醇具有潜在的神经再生作用，通过增加外周神经系统部位的髓鞘合成，固有地改善神经肌肉效率。
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