Liu Fangfang, Hang Dong, Deng Qiuju, Liu Mengfei, Xi Longfu, He Zhonghu, Zhang Chaoting, Sun Min, Liu Ying, Li Jingjing, Pan Yaqi, Ning Tao, Guo Chuanhai, Liang Yongmei, Xu Ruiping, Zhang Lixin, Cai Hong, Ke Yang
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Genetics, Peking University Cancer Hospital &Institute, Beijing, China.
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Sci Rep. 2015 Oct 27;5:15637. doi: 10.1038/srep15637.
Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected simultaneously from 2566 men in rural China. Using general primer-mediated (SPF1/GP6+) PCR and sequencing, HPV testing results were obtained from 2228 men with both valid oral and genital specimens (β-globin-positive). The prevalence of HPV infection was 6.7% in the oral cavity and 16.9% for the external genitalia. Among 43 men (1.9%, 43/2228) with oral-genital coinfection, 60.5% (26/43) harbored an identical HPV type at both sites. The risk of oral HPV infection was higher among men with genital infection than among uninfected men (11.4% vs. 5.7%, Adjusted OR = 2.3, 95% CI: 1.6-3.4). In addition, having multiple lifetime sexual partners was a significant risk for oral-genital HPV coinfection (Adjusted OR = 2.6, 95% CI: 1.0-7.0; 2 partners vs. 1 partner). These findings provide a basis for further understanding the natural history and transmission dynamics of oral HPV infection.
人乳头瘤病毒（HPV）感染是生殖器癌的主要病因，也与年轻男性口咽癌发病率上升有关。对于健康个体中口腔和生殖器感染并发的情况，人们了解相对较少。在中国农村地区，对2566名男性同时采集口腔和生殖器拭子脱落细胞。使用通用引物介导的（SPF1/GP6+）聚合酶链反应（PCR）和测序技术，从2228名口腔和生殖器标本均有效的男性（β-珠蛋白阳性）中获得了HPV检测结果。口腔HPV感染患病率为6.7%，外生殖器为16.9%。在43名（1.9%，43/2228）口腔-生殖器合并感染的男性中，60.5%（26/43）在两个部位携带相同的HPV型别。生殖器感染男性的口腔HPV感染风险高于未感染男性（11.4%对5.7%，校正比值比=2.3，95%可信区间：1.6-3.4）。此外，一生中拥有多个性伴侣是口腔-生殖器HPV合并感染的显著风险因素（校正比值比=2.6，95%可信区间：1.0-7.0；2个性伴侣对1个性伴侣）。这些发现为进一步了解口腔HPV感染的自然史和传播动态提供了依据。
