Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Korea.
Clinical Trial Specialist Program for In Vitro Diagnostics, Brain Busan 21 Plus Program, The Graduate School, Catholic University of Pusan, Busan 46252, Korea.
Int J Environ Res Public Health. 2021 Nov 8;18(21):11706. doi: 10.3390/ijerph182111706.
Human papillomavirus (HPV) infection in males is associated with various cancers, including cervical cancer in women and penile and bladder cancers in men. However, there is limited research on the prevalence and prevention of male HPV infection. Moreover, a rapid test that can prevent the increase in HPV infection is needed. In this study, the prevalence of sexually transmitted pathogen (STP) and HPV infection was analyzed using real-time polymerase chain reaction assay in random urine samples collected from asymptomatic male sexual partners of women with sexually transmitted diseases. Among 130 men, 65 (50.0%) had STP and 12 (9.23%) had HPV infection. There was no association between STP and HPV infection. Among 12 cases of HPV infection, three were HPV-16 single infections, six were multiple infections, including HPV-16, and three of other high-risk HPV infections. Our results suggest the need for STP testing, including HPV testing, in sexual partners of high-risk women with sexually transmitted diseases, even in men without clinical symptoms (asymptomatic). Further research should be conducted by diversifying urine samples. We report the most convenient method for HPV detection, and it is expected to be widely applied to prevent sexually transmitted diseases in men and women.
人乳头瘤病毒（HPV）感染与各种癌症有关，包括女性的宫颈癌和男性的阴茎癌和膀胱癌。然而，男性 HPV 感染的流行和预防研究有限。此外，还需要一种能够预防 HPV 感染增加的快速检测方法。在这项研究中，使用实时聚合酶链反应分析了随机尿液样本中来自患有性传播疾病的女性无症状性伴侣的性传播病原体（STP）和 HPV 感染的流行率。在 130 名男性中，有 65 名（50.0%）患有 STP，12 名（9.23%）患有 HPV 感染。STP 和 HPV 感染之间没有关联。在 12 例 HPV 感染中，3 例为 HPV-16 单一感染，6 例为包括 HPV-16 在内的多种感染，3 例为其他高危 HPV 感染。我们的研究结果表明，即使是无症状的性传播疾病高危女性的性伴侣也需要进行 STP 检测，包括 HPV 检测。需要进一步研究，通过多样化尿液样本来开展研究。我们报告了最方便的 HPV 检测方法，预计它将广泛应用于预防男女的性传播疾病。
