Chen Su, Wu Qihao, Shen Qingqing, Wang Hong
College of Pharmaceutical Science, Zhejiang University of Technology, Chaowang Road No.18, Xiacheng District, Hangzhou, 310014, Zhejiang, China.
Chembiochem. 2016 Jan;17(2):119-28. doi: 10.1002/cbic.201500542. Epub 2015 Nov 26.
Species of Amycolatopsis, well recognized as producers of both vancomycin and rifamycin, are also known for producing other secondary metabolites, with wide usage in medicine and agriculture. The molecular genetics of natural antibiotics produced by this genus have been well studied. Since the rise of antibiotic resistance, finding new drugs to fight infection has become an urgent priority. Progress in understanding the biosynthesis of metabolites greatly helps the rational manipulation of biosynthetic pathways, and thus to achieve the goal of generating novel natural antibiotics. The efforts made in exploiting Amycolatopsis genome sequences for the discovery of novel natural products and biosynthetic pathways are summarized.
被公认为是万古霉素和利福霉素生产者的拟无枝酸菌属，也因产生其他次级代谢产物而闻名，这些次级代谢产物在医学和农业中有着广泛的用途。该属产生的天然抗生素的分子遗传学已得到充分研究。自抗生素耐药性出现以来，寻找对抗感染的新药已成为当务之急。了解代谢产物生物合成方面的进展极大地有助于合理操控生物合成途径，从而实现生成新型天然抗生素的目标。本文总结了利用拟无枝酸菌属基因组序列发现新型天然产物和生物合成途径所做的努力。
