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铅的持续威胁:一个独特的机遇。

The persistent threat of lead: a singular opportunity.

作者信息

Needleman H L

机构信息

School of Medicine, University of Pittsburgh, PA 15213.

出版信息

Am J Public Health. 1989 May;79(5):643-5. doi: 10.2105/ajph.79.5.643.

DOI:10.2105/ajph.79.5.643
PMID:2650573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1349514/
Abstract

Recent data have demonstrated health effects of lead in children at doses previously believed to be harmless. Data from epidemiological studies in many countries, and from experimental studies of animals given lead, demonstrate psychological impairment at blood lead concentrations of 0.5-0.7 mumol/L. Current estimates are that 17 per cent of American children (3-4 million) exceed the level of 0.7 mumol/L. Lead exposure is not a problem for urban poor children alone, but inner-city minorities have a higher rate of exposure. The overabundance of lead coexists in the same area with two serious shortages: affordable housing and jobs. It is argued that a program to train unemployed inner-city residents in safe de-leading, while expensive, makes hygienic, economic, and common sense.

摘要

最近的数据表明,以前认为无害剂量的铅对儿童健康也有影响。许多国家的流行病学研究数据以及给动物喂食铅的实验研究数据表明,血铅浓度在0.5 - 0.7微摩尔/升时会出现心理障碍。目前估计,17%的美国儿童(300 - 400万)血铅水平超过0.7微摩尔/升。铅暴露并非仅仅是城市贫困儿童面临的问题,城市中心区的少数族裔接触铅的比例更高。铅含量过高与同一地区的两个严重短缺现象并存:经济适用房和就业机会。有人认为,一项培训城市中心区失业居民进行安全除铅的计划虽然成本高昂,但却符合卫生、经济和常识。

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The persistent threat of lead: a singular opportunity.铅的持续威胁:一个独特的机遇。
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Panel advises tougher limits on lead exposure.专家组建议对铅暴露采取更严格的限制措施。
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In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST.体外铅暴露会改变IGF2和PEG1/MEST的DNA甲基化及表达。
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Lead toxicity: current concerns.铅中毒:当前关注的问题。
Environ Health Perspect. 1993 Apr;100:177-87. doi: 10.1289/ehp.93100177.
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Internal lead and cadmium exposure in 6-year-old children from western and eastern Germany.德国西部和东部6岁儿童体内铅和镉的暴露情况。
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Warnings unheeded: a history of child lead poisoning.警告被忽视:儿童铅中毒史
Am J Public Health. 1989 Dec;79(12):1668-74. doi: 10.2105/ajph.79.12.1668.
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Soft plastic bread packaging: lead content and reuse by families.软质塑料面包包装:铅含量及家庭再利用情况
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本文引用的文献

1
Contributions of the caregiving environment to increased lead burden of children.
Am J Ment Defic. 1980 Jan;84(4):339-44.
2
Lead-associated intellectual deficit.铅相关智力缺陷。
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Chronological trend in blood lead levels between 1976 and 1980.1976年至1980年间血铅水平的时间趋势。
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Lead poisoning: a preventable childhood disease of the slums.铅中毒:一种可预防的贫民窟儿童疾病。
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Automated testing of reaction time and its association with lead in children.儿童反应时间的自动化测试及其与铅的关联。
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Relationship between childhood blood lead levels and stature.儿童血铅水平与身高之间的关系。
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7
Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development.产前和产后铅暴露与早期认知发展的纵向分析。
N Engl J Med. 1987 Apr 23;316(17):1037-43. doi: 10.1056/NEJM198704233161701.
8
Low-level lifetime lead exposure produces behavioral toxicity (spatial discrimination reversal) in adult monkeys.成年猴子长期低水平接触铅会产生行为毒性(空间辨别逆转)。
Toxicol Appl Pharmacol. 1987 Dec;91(3):484-90. doi: 10.1016/0041-008x(87)90070-6.
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Influence of blood lead on the ability and attainment of children in Edinburgh.血铅对爱丁堡儿童能力与学业成就的影响。
Lancet. 1987 May 30;1(8544):1221-6. doi: 10.1016/s0140-6736(87)92683-3.
10
Lead and child development.铅与儿童发育
Nature. 1987;329(6137):297-300. doi: 10.1038/329297a0.