Luan Chengxin, Yang Zixue, Chen Baoan
Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People's Republic of China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, People's Republic of China.
Onco Targets Ther. 2015 Oct 13;8:2903-14. doi: 10.2147/OTT.S92470. eCollection 2015.
MicroRNAs (miRNAs), a new class of noncoding RNAs, which can hybridize to target messenger RNAs and regulate their expression posttranscriptionally, express differentially in distinct stages of lymphopoiesis and influence the direction of lymphoid precursor maturation. Hence, there is aberrant expression of miRNAs involved in malignant lymphopoiesis, and these aberrations can be used as signatures of acute lymphoblastic leukemia (ALL) with different subtypes. In addition, changes in the expression of several miRNAs may have functional relevance with leukemogenesis or drug resistance. As a result, the reversal of the expression of these miRNAs may alleviate the disease to some extent and improve clinical outcomes. However, among the studies of miRNAs, there are still some problems that need to be solved to understand the function of miRNAs in ALL more thoroughly.
微小RNA（miRNA）是一类新型非编码RNA，可与靶信使RNA杂交并在转录后调节其表达，在淋巴细胞生成的不同阶段差异表达，并影响淋巴前体成熟的方向。因此，参与恶性淋巴细胞生成的miRNA存在异常表达，这些异常可作为不同亚型急性淋巴细胞白血病（ALL）的特征。此外，几种miRNA表达的变化可能与白血病发生或耐药性具有功能相关性。因此，这些miRNA表达的逆转可能在一定程度上缓解疾病并改善临床结果。然而，在miRNA的研究中，仍存在一些问题需要解决，以便更全面地了解miRNA在ALL中的功能。
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