Zhu Ming-Xia, Ke Xiao-Yan
Department of Hematology, Peking University Third Hospital, Beijing, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Aug;20(4):1014-9.
microRNAs (miRNAs) are small molecular non-coding RNA with 21-25 nucleotides in a variety of eukaryotic systems, and regulate gene expression at the post-transcriptional level by degrading or translational repressing target messenger RNA (mRNA). Many studies have showed the roles of miRNAs in normal lymphocytopoiesis, giving an interpretative key to the aberrant expression observed in human lymphoid malignancies. The recent advances of understanding the roles of miRNAs in lymphoid malignancies show that miRNAs as tumoral biomarkers can effectively be used for diagnosis, prognosis, and prediction of response to therapy. This review focuses the roles of miRNA in development and differentiation of lymphocytes and the relation of miRNA to lymphoid malignancies.
微小RNA（miRNA）是一类小分子非编码RNA，在多种真核生物系统中长度为21-25个核苷酸，通过降解靶信使核糖核酸（mRNA）或抑制其翻译在转录后水平调控基因表达。许多研究已表明miRNA在正常淋巴细胞生成中的作用，为在人类淋巴恶性肿瘤中观察到的异常表达提供了解释关键。近期在理解miRNA在淋巴恶性肿瘤中作用方面的进展表明，miRNA作为肿瘤生物标志物可有效用于诊断、预后评估及治疗反应预测。本综述聚焦于miRNA在淋巴细胞发育和分化中的作用以及miRNA与淋巴恶性肿瘤的关系。
