Arias Á, Pérez-Martínez I, Tenías J M, Lucendo A J
Research Unit, Complejo Hospitalario La Mancha Centro, Alcázar de San Juan, Spain.
Department of Gastroenterology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Aliment Pharmacol Ther. 2016 Jan;43(1):3-15. doi: 10.1111/apt.13441. Epub 2015 Oct 28.
The recognition of eosinophilic oesophagitis (EoE) has risen sharply, but its current epidemiology is still under debate.
To estimate accurately the prevalence and incidence rates of EoE, by a systematic review and meta-analysis.
MEDLINE, EMBASE and SCOPUS databases were searched for population-based studies on the epidemiology of EoE. Pooled incidence and prevalence rates, male:female and children:adult ratios, and geographical and temporal variations were calculated with random-effects models.
The search yielded 1334 references; the final quantitative summary included 13 population-based studies from North America, Europe and Australia, with the results showing high heterogeneity. The pooled EoE incidence rate was 3.7/100 000 persons/year [95% confidence interval (CI): 1.7-6.5] and was higher for adults (7; 95% CI: 1-18.3) than for children (5.1; 95% CI: 1.5-10.9). The pooled prevalence of EoE was 22.7 cases/100 000 inhabitants (95% CI: 12.4-36), rising to 28.1 (95% CI: 13-49) when studies with a lower risk of bias were considered; prevalence was higher in adults than in children (43.4; 95% CI: 22.5-71.2 vs. 29.5; 95% CI: 17.5-44.7, respectively), and in American compared to European studies. A steady rise in EoE incidence and prevalence rates was observed upon comparison of studies conducted before and after 2008. No significant publication bias was found.
Eosinophilic oesophagitis is an increasingly common diagnosis in North America and Europe. The population-based incidence and prevalence of eosinophilic oesophagitis vary widely across individual studies, probably due to variations in diagnosis and risk of bias of research. More prospective, large-scale, multicenter studies are needed to evaluate reported data.
嗜酸性粒细胞性食管炎（EoE）的诊断率急剧上升，但其目前的流行病学仍存在争议。
通过系统评价和荟萃分析准确估计EoE的患病率和发病率。
检索MEDLINE、EMBASE和SCOPUS数据库中关于EoE流行病学的基于人群的研究。采用随机效应模型计算合并发病率和患病率、男女性别比、儿童与成人比例以及地理和时间差异。
检索获得1334篇参考文献；最终的定量总结纳入了来自北美、欧洲和澳大利亚的13项基于人群的研究，结果显示高度异质性。EoE合并发病率为3.7/100 000人/年[95%置信区间（CI）：1.7 - 6.5]，成人发病率（7；95% CI：1 - 18.3）高于儿童（5.1；95% CI：1.5 - 10.9）。EoE合并患病率为22.7例/100 000居民（95% CI：12.4 - 36），若考虑偏倚风险较低的研究，患病率升至28.1（95% CI：13 - 49）；成人患病率高于儿童（分别为每100 000居民43.4例；95% CI：22.5 - 71.2和每100 000居民29.5例；95% CI：17.5 - 44.7），且美国研究中的患病率高于欧洲研究。比较2008年前后开展的研究发现，EoE发病率和患病率呈稳步上升趋势。未发现明显的发表偏倚。
嗜酸性粒细胞性食管炎在北美和欧洲是一种越来越常见的诊断疾病。基于人群的嗜酸性粒细胞性食管炎发病率和患病率在各个研究中差异很大，可能是由于诊断差异和研究偏倚风险不同。需要更多前瞻性、大规模、多中心研究来评估所报告的数据。
