Bonuccelli U, Melis G B, Paoletti A M, Fioretti P, Murri L, Muratorio A
Rush-Presbyterian-St. Luke's Medical Center, Department of Neurological Sciences, Chicago, IL 60612.
Epilepsy Res. 1989 Mar-Apr;3(2):100-6. doi: 10.1016/0920-1211(89)90037-5.
Ten women with a documented history of catamenial epilepsy underwent a hormonal study to evaluate hypophyseal-gonadal function. Baseline values of luteinizing hormone, follicle-stimulating hormone and prolactin were similar in catamenial seizure patients and in control groups throughout a complete menstrual cycle. Stimulated secretions of the same hypophyseal hormones in catamenial seizure patients overlapped those of the controls. The luteal secretion ratio of progesterone to estradiol was significantly reduced in catamenial seizure patients versus normal controls. In a subgroup of catamenial seizure patients on antiepileptic therapy, luteal progesterone levels were remarkably decreased compared to normal and epileptic controls. These results indicate that catamenial epilepsy is characterized by an imbalance in ovarian steroid secretion and emphasize the need for an endocrinological assessment in these patients.
十名有经期性癫痫病史记录的女性接受了一项激素研究，以评估垂体-性腺功能。在整个完整月经周期中，经期性癫痫患者和对照组的促黄体生成素、促卵泡生成素和催乳素的基线值相似。经期性癫痫患者中相同垂体激素的刺激分泌与对照组重叠。与正常对照组相比，经期性癫痫患者中孕酮与雌二醇的黄体分泌率显著降低。在接受抗癫痫治疗的经期性癫痫患者亚组中，黄体孕酮水平与正常和癫痫对照组相比显著降低。这些结果表明，经期性癫痫的特征是卵巢类固醇分泌失衡，并强调了对这些患者进行内分泌评估的必要性。
