Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Sci China Life Sci. 2015 Nov;58(11):1089-98. doi: 10.1007/s11427-015-4956-7. Epub 2015 Oct 28.
Orderly execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister chromatid cohesion. Timely establishment and dissolution of sister chromatid cohesion is a prerequisite for accurate chromosome segregation, and is tight regulated by the cell cycle machinery and cohesin-associated proteins. In this review, we discuss recent progress in the molecular understanding of sister chromatid cohesion during the mitotic cell cycle.
细胞周期中两个关键事件的有序执行--DNA 复制和染色体分离--确保了遗传物质的稳定传递。在称为姐妹染色单体黏合的过程中，黏合复合物在 DNA 复制期间物理连接姐妹染色单体。姐妹染色单体黏合的及时建立和溶解是准确染色体分离的前提，并且受到细胞周期机制和黏合相关蛋白的严格调节。在这篇综述中，我们讨论了对有丝分裂细胞周期中姐妹染色单体黏合的分子理解的最新进展。
