Kuhn H Georg
Center for Brain Repair and Rehabilitation, Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg 413 90, Sweden.
Cold Spring Harb Perspect Biol. 2015 Oct 28;7(12):a018895. doi: 10.1101/cshperspect.a018895.
The fact that continuous proliferation of stem cells and progenitors, as well as the production of new neurons, occurs in the adult mammalian central nervous system (CNS) raises several basic questions concerning the number of neurons required in a particular system. Can we observe continued growth of brain regions that sustain neurogenesis? Or does an elimination mechanism exist to maintain a constant number of cells? If so, are old neurons replaced, or are the new neurons competing for limited network access among each other? What signals support their survival and integration and what factors are responsible for their elimination? This review will address these and other questions regarding regulatory mechanisms that control cell-death and cell-survival mechanisms during neurogenesis in the intact adult mammalian brain.
成年哺乳动物中枢神经系统（CNS）中干细胞和祖细胞持续增殖以及新神经元产生这一事实，引发了几个关于特定系统所需神经元数量的基本问题。我们能否观察到维持神经发生的脑区持续生长？或者是否存在一种消除机制来维持细胞数量恒定？如果是这样，旧神经元会被替换吗？还是新神经元在相互竞争有限的网络接入机会？哪些信号支持它们的存活和整合，哪些因素导致它们被消除？本综述将探讨这些以及其他有关在完整成年哺乳动物大脑神经发生过程中控制细胞死亡和细胞存活机制的调节机制的问题。
