环孢素A对活动性克罗恩病的影响。

Effects of cyclosporin A on active Crohn's disease.

作者信息

Fukushima T, Sugita A, Masuzawa S, Yamazaki Y, Tsuchiya S

机构信息

Second Department of Surgery, Yokohama City University, School of Medicine, Japan.

出版信息

Gastroenterol Jpn. 1989 Feb;24(1):12-5. doi: 10.1007/BF02774864.

DOI:10.1007/BF02774864

PMID:2651204

Abstract

Seven patients with active Crohn's disease were treated with cyclosporin A orally for 16 weeks. The initial dose was 8 mg/kg/day and the subsequent dose was adjusted to maintain the plasma concentration of cyclosporin A of approximately 200 ng/ml. The mean value of the Crohn's disease activity index before treatment was 194.3 +/- 57.4. It was gradually decreased reaching a nadir at 12 weeks (139.0 +/- 45.6, p less than 0.05) and one enterocutaneous fistula was closed. White blood cell counts, hemoglobin and alpha-2-globulin did not significantly improve during treatment. Cyclosporin A could be indicated when steroids, sulfasalazine or azathioprine are not effective or not tolerated.

摘要

7例活动期克罗恩病患者口服环孢素A治疗16周。初始剂量为8mg/kg/天，随后调整剂量以维持环孢素A血浆浓度约为200ng/ml。治疗前克罗恩病活动指数的平均值为194.3±57.4。该指数逐渐下降，在12周时达到最低点（139.0±45.6，p<0.05），1例肠皮肤瘘闭合。治疗期间白细胞计数、血红蛋白和α2球蛋白无明显改善。当类固醇、柳氮磺胺吡啶或硫唑嘌呤无效或不能耐受时，可使用环孢素A。