Dannecker G, Malchow H, Niessen K H, Ranke M B
Dtsch Med Wochenschr. 1985 Mar 1;110(9):339-43. doi: 10.1055/s-2008-1068824.
The diagnosis of Crohn's disease with extensive involvement of small intestine and colon was first made in a 12 3/4-year-old girl, now 15 1/2 years old. Despite continued treatment with prednisolone and salazosulfapyridine, as well as azathioprine and metronidazole, no lasting remission was obtained. Widespread severe osteoporosis with vertebral fractures made it necessary to discontinue the prednisolone, despite endoscopically and biochemically confirmed signs of activity of the disease. Administration of cyclosporin A in this situation produced phases of improved clinical and biochemical parameters. Regular control of biochemical levels failed to reveal any drug-specific acute side-effects. Because of the increased incidence of malignant lymphoma under cyclosporin A this drug should be held in reserve in the treatment of Crohn's disease, until results from controlled studies have become available.
一名12又3/4岁女孩首次被诊断出患有广泛累及小肠和结肠的克罗恩病，如今她已15又1/2岁。尽管持续使用泼尼松龙、柳氮磺胺吡啶以及硫唑嘌呤和甲硝唑进行治疗，但仍未获得持久缓解。广泛的严重骨质疏松伴椎体骨折使得尽管内镜和生化检查证实疾病有活动迹象，也不得不停用泼尼松龙。在这种情况下给予环孢素A使临床和生化参数出现改善阶段。定期监测生化指标未发现任何药物特异性急性副作用。鉴于环孢素A治疗下恶性淋巴瘤发病率增加，在克罗恩病治疗中应保留该药物，直至获得对照研究结果。
