Parrott N R, Taylor R M, Venables C W, Record C O
Department of Surgery, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Br J Surg. 1988 Dec;75(12):1185-8. doi: 10.1002/bjs.1800751213.
It has been suggested that cyclosporin A might be of some benefit to patients with Crohn's disease. The clinical response and side-effects of cyclosporin A in Crohn's disease are described in a series of 13 adults. The majority of patients had ileal disease and all but one were started on an initial oral dose of 15 mg/kg per day. Duration of treatment ranged from 3 to 42 weeks. Of the 13 patients, 6 showed a response to therapy; the remainder showed no response or deteriorated. The commonest side-effect was hyperaesthesia, but one patient developed nephrotoxicity and one developed hepatotoxicity. Significant drug malabsorption occurred in one case. The side-effects were dose dependent and reversible. Cyclosporin A may have a part to play in the treatment of resistant Crohn's disease, and in our hands has been associated with a 46 per cent response rate; however, the precise role of cyclosporin A in the management of Crohn's disease awaits further study.
有人提出环孢素A可能对克罗恩病患者有益。本文描述了13例成年克罗恩病患者使用环孢素A的临床反应及副作用。大多数患者患有回肠疾病，除1例患者外，所有患者均以每日15mg/kg的初始口服剂量开始治疗。治疗持续时间为3至42周。13例患者中，6例对治疗有反应；其余患者无反应或病情恶化。最常见的副作用是感觉过敏，但有1例患者出现肾毒性，1例出现肝毒性。1例患者出现明显的药物吸收不良。副作用与剂量相关且可逆转。环孢素A可能在难治性克罗恩病的治疗中发挥作用，在我们的研究中其有效率为46%；然而，环孢素A在克罗恩病治疗中的确切作用仍有待进一步研究。
