微小RNA对心血管衰老的影响。
Impact of miRNAs on cardiovascular aging.
作者信息
Lee Seahyoung, Choi Eunhyun, Cha Min-Ji, Park Ae-Jun, Yoon Cheesoon, Hwang Ki-Chul
机构信息
Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea ; Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City, South Korea.
Department of Healthcare Management, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwond-do, South Korea.
出版信息
J Geriatr Cardiol. 2015 Sep;12(5):569-74. doi: 10.11909/j.issn.1671-5411.2015.05.011.
Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs (miRNAs) have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging.
衰老 是一个多维度的过程，会增加患严重疾病的风险，如癌症、心血管疾病、神经退行性疾病和免疫性疾病。最近，被称为微小RNA（miRNA）的小型非编码RNA已被证明可调节基因表达，这在人类许多生理和病理生理过程中发挥作用。越来越多的证据表明，miRNA表达谱的变化与细胞衰老、衰老及衰老相关疾病有关。然而，目前仅阐明了少数几种miRNA的功能与衰老和/或衰老相关疾病有关。本文综述了目前关于衰老相关miRNA作用的现有研究结果，重点关注心脏和心血管衰老。
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