School of Basic Medicine, Dali University, Dali, Yunnan, 671000, China.
Key Laboratory of University Cell Biology, Dali, Yunnan, 671000, China.
Curr Stem Cell Res Ther. 2024;19(3):334-350. doi: 10.2174/1574888X18666230308111043.
Senescence refers to the irreversible state in which cells enter cell cycle arrest due to internal or external stimuli. The accumulation of senescent cells can lead to many age-related diseases, such as neurodegenerative diseases, cardiovascular diseases, and cancers. MicroRNAs are short non-coding RNAs that bind to target mRNA to regulate gene expression after transcription and play an important regulatory role in the aging process. From nematodes to humans, a variety of miRNAs have been confirmed to alter and affect the aging process. Studying the regulatory mechanisms of miRNAs in aging can further deepen our understanding of cell and body aging and provide a new perspective for the diagnosis and treatment of aging-related diseases. In this review, we illustrate the current research status of miRNAs in aging and discuss the possible prospects for clinical applications of targeting miRNAs in senile diseases.
衰老指细胞由于内部或外部刺激而进入细胞周期停滞的不可逆状态。衰老细胞的积累可导致许多与年龄相关的疾病，如神经退行性疾病、心血管疾病和癌症。miRNAs 是短的非编码 RNA，在转录后与靶 mRNA 结合以调节基因表达，在衰老过程中发挥重要的调节作用。从线虫到人类，已经证实多种 miRNAs 可以改变和影响衰老过程。研究 miRNAs 在衰老中的调控机制可以进一步加深我们对细胞和机体衰老的理解，并为衰老相关疾病的诊断和治疗提供新的视角。在这篇综述中，我们阐述了 miRNAs 在衰老中的研究现状，并讨论了针对衰老相关疾病中 miRNAs 的靶向治疗的可能临床应用前景。
