抑郁症患者血清中丝氨酸对映体水平升高。
Increased serum levels of serine enantiomers in patients with depression.
作者信息
Hashimoto Kenji, Yoshida Taisuke, Ishikawa Masatomo, Fujita Yuko, Niitsu Tomihisa, Nakazato Michiko, Watanabe Hiroyuki, Sasaki Tsuyoshi, Shiina Akihiro, Hashimoto Tasuku, Kanahara Nobuhisa, Hasegawa Tadashi, Enohara Masayo, Kimura Atsushi, Iyo Masaomi
机构信息
1Division of Clinical Neuroscience,Chiba University Center for Forensic Mental Health,Chiba,Japan.
2Department of Psychiatry,Chiba University Graduate School of Medicine,Chiba,Japan.
出版信息
Acta Neuropsychiatr. 2016 Jun;28(3):173-8. doi: 10.1017/neu.2015.59. Epub 2015 Oct 29.
OBJECTIVE
Glutamatergic neurotransmission via the N-methyl-d-aspartate (NMDA) receptor is integral to the pathophysiology of depression. This study was performed to examine whether amino acids related to NMDA receptor neurotransmission are altered in the serum of patients with depression.
METHOD
We measured the serum levels of d-serine, l-serine, glycine, glutamate and glutamine in patients with depression (n=70), and age-matched healthy subjects (n=78).
RESULTS
Serum levels of d-serine and l-serine in patients with depression were significantly higher than those of healthy controls (p<0.001). In contrast, serum levels of glycine, glutamate and glutamine did not differ between the two groups. Interestingly, the ratio of l-serine to glycine in patients was significantly higher than that of healthy controls (p<0.001).
CONCLUSION
This study suggests that serine enantiomers may be peripheral biomarkers for depression, and that abnormality in the d-serine-l-serine-glycine cycle plays a role in the pathophysiology of depression.
目的
通过N-甲基-D-天冬氨酸（NMDA）受体的谷氨酸能神经传递是抑郁症病理生理学的一个组成部分。本研究旨在探讨与NMDA受体神经传递相关的氨基酸在抑郁症患者血清中是否发生改变。
方法
我们测量了抑郁症患者（n=70）和年龄匹配的健康受试者（n=78）血清中D-丝氨酸、L-丝氨酸、甘氨酸、谷氨酸和谷氨酰胺的水平。
结果
抑郁症患者血清中D-丝氨酸和L-丝氨酸水平显著高于健康对照组（p<0.001）。相比之下，两组之间甘氨酸、谷氨酸和谷氨酰胺的血清水平没有差异。有趣的是，患者中L-丝氨酸与甘氨酸的比值显著高于健康对照组（p<0.001）。
结论
本研究表明丝氨酸对映体可能是抑郁症的外周生物标志物，并且D-丝氨酸-L-丝氨酸-甘氨酸循环异常在抑郁症的病理生理学中起作用。
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