Hirano T, Taga T, Yamasaki K, Matsuda T, Tang B, Muraguchi A, Horii Y, Suematsu S, Hirata Y, Yawata H
Institute for Molecular and Cellular Biology, Osaka University, Japan.
Int Arch Allergy Appl Immunol. 1989;88(1-2):29-33. doi: 10.1159/000234743.
Interleukin 6 (IL-6)/B cell stimulatory factor 2 is a multifunctional cytokine produced by both lymphoid and nonlymphoid cells. IL-6 regulates immune response, acute phase reaction, and hematopoiesis. It was found that IL-6 production by T cells is dependent on macrophages, and IL-6 is one of essential factors for pokeweed mitogen induced immunoglobulin production. Both high- and low-affinity IL-6 receptors were identified. The molecular cloning of IL-6 receptors demonstrated that this receptor is a member of the immunoglobulin superfamily. The deregulated production of IL-6 is suggested to be involved in the pathogenesis of autoimmune diseases and in the development of multiple myeloma.
白细胞介素6（IL-6）/B细胞刺激因子2是一种由淋巴细胞和非淋巴细胞产生的多功能细胞因子。IL-6调节免疫反应、急性期反应和造血作用。研究发现，T细胞产生IL-6依赖于巨噬细胞，且IL-6是商陆有丝分裂原诱导免疫球蛋白产生的关键因素之一。已鉴定出高亲和力和低亲和力的IL-6受体。IL-6受体的分子克隆表明，该受体是免疫球蛋白超家族的成员。IL-6的失控产生被认为与自身免疫性疾病的发病机制以及多发性骨髓瘤的发展有关。
