Sentürk T, Kinikli G, Turgay M, Tutkak H, Duman M, Tokgöz G
Department of Immunology, Medical School, Ankara University, Turkey.
Rheumatol Int. 1996;16(4):141-4. doi: 10.1007/BF01419726.
This study evaluated interleukin-6 levels as an activity criterion in rheumatoid arthritis (RA) and compared if with other activity criteria. We evaluated 35 patients with active RA, 31 with inactive RA, and 25 patients with osteoarthritis, in addition to 28 healthy individuals. Serum interleukin-6 levels were higher in active RA patients than in those with inactive RA, or osteoarthritis and healthy individuals (P < 0.001). Serum interleukin-6 levels of patients with active RA were positively correlated with the erythrocyte sedimentation rate, C-reactive protein, and alpha 2-globulin levels (P < 0.001), but there was a negative correlation with serum albumin levels (P < 0.05). We conclude that interleukin-6 can be responsible for both the most systemic manifestations of RA and for its local manifestations.
本研究评估了白细胞介素-6水平作为类风湿关节炎（RA）活动标准，并将其与其他活动标准进行比较。我们评估了35例活动期RA患者、31例非活动期RA患者、25例骨关节炎患者以及28名健康个体。活动期RA患者的血清白细胞介素-6水平高于非活动期RA患者、骨关节炎患者及健康个体（P<0.001）。活动期RA患者的血清白细胞介素-6水平与红细胞沉降率、C反应蛋白及α2球蛋白水平呈正相关（P<0.001），但与血清白蛋白水平呈负相关（P<0.05）。我们得出结论，白细胞介素-6可能是RA全身表现和局部表现的病因。
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