The effect of TP-5 on the production of C3, PGE2, and TXB2 by macrophages obtained from burned guinea pigs.

The effect of in vivo administration of the immunomodulator TP-5 on the in vitro synthesis and release of C3, PGE2, and TXB2 by guinea pig alveolar, splenic, and peritoneal macrophages was studied. Three groups of animals were studied: unburned control, burned, and burned + TP-5. There was no significant difference in the production of C3, PGE2, or TXB2, by alveolar macrophages of the three groups of animals or by splenic macrophages of the three groups. There was a significant difference in the production of TXB2 by peritoneal macrophages between the unburned control compared with the burned and burned plus TP-5 groups. Our conclusion is that peritoneal macrophages seem to be controlled by mechanisms that are different from those that control alveolar or splenic macrophages.