The production of C3, PGE2 and TxB2 by splenic, alveolar, and peritoneal guinea pig macrophages.

The synthesis and release of C3, PGE2, and TxB2 by cultured splenic, alveolar and peritoneal guinea pig macrophages in 24 hour culture was determined. There were significant differences in C3 production among all three sources of macrophages. Splenic macrophages produced significantly less PGE2 than alveolar or peritoneal macrophages. Peritoneal macrophages produced significantly more TxB2 than splenic or alveolar macrophages. The cells from the different sources appear to be different populations of macrophages.