Jalil Nur Asyilla Che, Zin Anani Aila Mat, Othman Nor Hayati
Department of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Malaysia E-mail :
Asian Pac J Cancer Prev. 2015;16(16):7267-70. doi: 10.7314/apjcp.2015.16.16.7267.
Kelantan is one of the states in Malaysia which has a high prevalence of type 2 diabetes (DM2). Other than with endometrial carcinoma, the association of DM2 with particular female cancers is not known.
To determine the proportion of breast, cervical, ovarian and endometrial cancers among females with DM2 diagnosed in Hospital Universiti Sains Malaysia (HUSM) over an 11 year period.
All histologically confirmed cases of breast, endometrial, cervical and ovarian carcinomas admitted to the Hospital were included in the study. The patient diabetic status was traced from the hospital medical records.
There was a total of 860 cases of breast, cervical, ovarian and endometrial carcinomas over this period. Breast carcinoma was the commonest, accounting for 437/860 (50.8%) followed by cervix, 159/860 (18.5%), ovarian, 143/860 (16.6%) and endometrial carcinomas, 121/860 (14.1%). Out of these, 228/860 (26.5%) were confirmed diabetics. Endometrial carcinoma patients showed the highest proportion being diabetics, 42.1% (51/121), followed by ovarian cancer, 25.9% (37/143), breast carcinoma, 23.6% (103/437) and cervical cancer 23.3% (37/159).
There is a significant proportion of DM2 among women with these four cancers, endometrial carcinoma being the highest followed by ovarian, breast and cervical carcinoma. The rising trend of these four cancers is in tandem with an increasing trend of DM2 in the community. In populations where diabetes is prevalent, screening for epithelial cancers should be rigourous. Diabetic clinics should include screening for these cancers among their female patients and gynecology clinics should screen the women they treat for their diabetes status.
吉兰丹是马来西亚糖尿病患病率较高的州之一。除子宫内膜癌外，2型糖尿病（DM2）与特定女性癌症之间的关联尚不清楚。
确定在11年期间马来西亚理科大学医院（HUSM）确诊的患有DM2的女性中乳腺癌、宫颈癌、卵巢癌和子宫内膜癌的比例。
纳入医院收治的所有经组织学确诊的乳腺癌、子宫内膜癌、宫颈癌和卵巢癌病例。从医院病历中追溯患者的糖尿病状况。
在此期间，共有860例乳腺癌、宫颈癌、卵巢癌和子宫内膜癌病例。乳腺癌最为常见，占437/860（50.8%），其次是宫颈癌，159/860（18.5%），卵巢癌，143/860（16.6%），子宫内膜癌，121/860（14.1%）。其中，228/860（26.5%）被确诊为糖尿病患者。子宫内膜癌患者中糖尿病患者的比例最高，为42.1%（51/121），其次是卵巢癌，25.9%（37/143），乳腺癌，23.6%（103/437），宫颈癌23.3%（37/159）。
在这四种癌症的女性患者中，DM2的比例相当高，子宫内膜癌患者中DM2比例最高，其次是卵巢癌、乳腺癌和宫颈癌。这四种癌症的上升趋势与社区中DM2的上升趋势一致。在糖尿病流行的人群中，上皮癌的筛查应该更加严格。糖尿病诊所应将这些癌症的筛查纳入其女性患者的检查项目中，妇科诊所应对其治疗的女性进行糖尿病状况筛查。
