Othman Nor Hayati, Zin Anani Aila Mat
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Asian Pac J Cancer Prev. 2008 Oct-Dec;9(4):747-51.
Kelantan in Malaysia has a high prevalence of diabetes and colorectal cancer is also on the rise. This study is to determine the association of metabolic diseases, particularly diabetes type 2 [DM2] and hypertension, with colorectal cancer patients in our population.
This retrospective study was conducted on all colorectal carcinomas in Hospital Universiti Sains Malaysia (HUSM) in Kelantan from ythe ears 2001-2006. The data were retrieved from the Registry in Pathology laboratory and the clinical details from the patients' clinical records and analyzed using SSPS Version 12.0, with a value of p<0.05 taken to be statistically significant.
138 CRC cases with complete clinical records were included. The age ranged from 16.0 to 88.0 years, with a mean of 56.9 -/+ SD 15.4. The male 90(65%) to female 48(35%) ratio was 1.7:1.0 and 47.8% were suffering from metabolic diseases; 18(13.0%) with Diabetes Mellitus Type 2(DM2), and 48(34.8%) with hypertension (HT). Diabetes Type 2 and hypertension also demonstrated significant association (p<0.05) with the stage and the site of the cancer. Patients with diabetes type 2 88.8%(16/18) and Hypertension 85.4% (41/48) were strongly associated with cancers located in the distal to transverse colon (p<0.001).
There is a high proportion of metabolic diseases; hypertension and diabetes type 2 among colorectal carcinomas seen in Kelantan population. In this preliminary study we noted a strong association of metabolic diseases with the stage and site of the cancer. To reduce CRC incidence, the high prevalence of DM2 in Kelantan needs to be addressed.
马来西亚吉兰丹州糖尿病患病率较高，结直肠癌发病率也呈上升趋势。本研究旨在确定代谢性疾病，特别是2型糖尿病（DM2）和高血压与我们研究人群中结直肠癌患者的关联。
本回顾性研究针对2001年至2006年期间吉兰丹州马来西亚理科大学医院（HUSM）的所有结直肠癌病例进行。数据从病理实验室登记处获取，临床细节从患者临床记录中获取，并使用SSPS 12.0版本进行分析，p值<0.05被认为具有统计学意义。
纳入138例有完整临床记录的结直肠癌病例。年龄范围为16.0至88.0岁，平均年龄为56.9±标准差15.4。男性90例（65%），女性48例（35%），男女比例为1.7:1.0，47.8%患有代谢性疾病；18例（13.0%）患有2型糖尿病（DM2），48例（34.8%）患有高血压（HT）。2型糖尿病和高血压与癌症分期及部位也存在显著关联（p<0.05）。2型糖尿病患者中88.8%（16/18）以及高血压患者中85.4%（41/48）与位于结肠远端至横结肠的癌症密切相关（p<0.001）。
在吉兰丹州人群中所见的结直肠癌患者中，代谢性疾病（高血压和2型糖尿病）比例较高。在这项初步研究中，我们注意到代谢性疾病与癌症分期及部位密切相关。为降低结直肠癌发病率，需要解决吉兰丹州2型糖尿病的高患病率问题。
