Mogren I, Stenlund H, Högberg U
Department of Clinical Science, Umeå University, Sweden.
Acta Oncol. 2001;40(7):849-54. doi: 10.1080/02841860152703481.
The influence of maternal age, parity, low or high birthweight, multiple births, and pre-eclampsia on the risk of cervical, endometrial, ovarian and breast cancers was studied. Data on 40951 women and the outcomes of their deliveries between 1955 and 1995 were obtained from birth registers. For the mothers, data from the Swedish Cancer Registry and the Cause of Death Register were added. The sample was evaluated using Cox's regression in univariate and bivariate analyses where the relative risk and its 95% confidence interval were calculated. Increasing maternal age at first birth was associated with an increasing relative risk of endometrial, ovarian, and breast cancers, and with a decreased risk of cervical cancer. Multiparity was a protective factor for all gynaecological cancers, including cervical and breast cancers. Multiple births were associated with an increased risk of endometrial cancer.
研究了产妇年龄、产次、低出生体重或高出生体重、多胎妊娠和先兆子痫对宫颈癌、子宫内膜癌、卵巢癌和乳腺癌风险的影响。1955年至1995年间40951名妇女及其分娩结局的数据来自出生登记册。对于母亲们，还补充了瑞典癌症登记处和死亡原因登记处的数据。在单变量和双变量分析中使用Cox回归对样本进行评估，计算相对风险及其95%置信区间。初产时产妇年龄增加与子宫内膜癌、卵巢癌和乳腺癌的相对风险增加以及宫颈癌风险降低相关。多产是包括宫颈癌和乳腺癌在内的所有妇科癌症的保护因素。多胎妊娠与子宫内膜癌风险增加相关。
