Institute of Biological Sciences, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Chemistry Department, Faculty of Science, University Malaya, 50603, Kuala Lumpur, Malaysia.
Environ Sci Pollut Res Int. 2015 Dec;22(24):19434-50. doi: 10.1007/s11356-015-5597-x. Epub 2015 Oct 29.
Dioxin-like compounds (DLCs) have been classified by the World Health Organization (WHO) as one of the most persistent toxic chemical substances in the environment, and they are associated with several occupational activities and industrial accidents around the world. Since the end of the 1970s, these toxic chemicals have been banned because of their human toxicity potential, long half-life, wide dispersion, and they bioaccumulate in the food web. This review serves as a primer for environmental health professionals to provide guidance on short-term risk assessment of dioxin and to identify key findings for health and exposure assessment based on policies of different agencies. It also presents possible health effects of dioxins, mechanisms of action, toxic equivalency factors (TEFs), and dose-response characterization. Key studies related to toxicity values of dioxin-like compounds and their possible human health risk were identified through PubMed and supplemented with relevant studies characterized by reviewing the reference lists in the review articles and primary literature. Existing data decreases the scope of analyses and models in relevant studies to a manageable size by focusing on the set of important studies related to the perspective of developing toxicity values of DLCs.
二恶英类化合物（DLCs）已被世界卫生组织（WHO）列为环境中最持久的有毒化学物质之一，与世界范围内的一些职业活动和工业事故有关。自 20 世纪 70 年代末以来，由于其对人类的毒性潜力、半衰期长、广泛分布以及在食物链中生物累积的特性，这些有毒化学品已被禁止使用。本综述旨在为环境卫生专业人员提供有关二恶英短期风险评估的指南，并根据不同机构的政策确定健康和暴露评估的关键发现。它还介绍了二恶英的可能健康影响、作用机制、毒性等效因子（TEFs）和剂量反应特征。通过 PubMed 确定了与二恶英类化合物毒性值及其可能的人类健康风险相关的关键研究，并通过查阅综述文章和主要文献中的相关研究，补充了相关研究的特征。现有数据通过关注与 DLCs 毒性值开发相关的重要研究，将相关研究中的分析和模型范围缩小到可管理的大小。
