Tian Yi, Fujibayashi Shunsuke, Yamaguchi Seiji, Matsushita Tomiharu, Kokubo Tadashi, Matsuda Shuichi
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shougoin, Sakyou-ku, Kyoto, 606-8507, Japan.
Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan.
J Mater Sci Mater Med. 2015 Dec;26(12):271. doi: 10.1007/s10856-015-5612-2. Epub 2015 Oct 29.
Alkali and heat (AH) treatment forming sodium titanate has been shown to connect bioinert Ti metal and bone tissue. Artificial joints treated with this method have achieved extensive clinical application. Recently a new chemical treatment of Alkali-Calcium-Heat-Water (ACaHW) treatment forming calcium titanate was proposed. Notably, the apatite-forming ability of this treatment is greater than that of AH treatment, as verified in vitro. However, the early bone-bonding abilities of the two treatments have not been compared in vivo. To simulate clinical application, we treated a commercially pure Ti (Cp-Ti) mesh implant with AH or ACaHW. Then, using mechanical and histological methods, we compared the bone-bonding abilities of the two treatments early during the implantation process (2-4 weeks); untreated Cp-Ti mesh was used as a control. Because the mesh structure might influence bone-bonding ability, we compared these bonding abilities with values obtained at 4 and 8 weeks using a Cp-Ti implant with a plate structure. In the mesh group, histological comparisons at 2 and 3 weeks indicated that ACaHW treatment resulted in a bone-bonding ability similar to that of AH treatment; ACaHW exhibited a greater bonding ability than AH at 4 weeks. However, in tests of the plate group at later time points, such differences were not apparent. The results obtained here indicate that during the early stage of embedment, ACaHW treatment of Cp-Ti mesh implants yields a higher bone-bonding ability than AH treatment, thus providing a positive reference for future clinical applications.
已证明通过碱热（AH）处理形成钛酸钠可将生物惰性钛金属与骨组织连接起来。用这种方法处理的人工关节已在临床上广泛应用。最近，有人提出了一种新的化学处理方法，即碱 - 钙 - 热 - 水（ACaHW）处理形成钛酸钙。值得注意的是，体外实验证实，这种处理方法的磷灰石形成能力大于AH处理。然而，这两种处理方法的早期骨结合能力尚未在体内进行比较。为模拟临床应用，我们用AH或ACaHW处理了商业纯钛（Cp-Ti）网状植入物。然后，我们使用力学和组织学方法，比较了植入过程早期（2 - 4周）这两种处理方法的骨结合能力；未处理的Cp-Ti网用作对照。由于网状结构可能会影响骨结合能力，我们将这些结合能力与使用板状结构的Cp-Ti植入物在4周和8周时获得的值进行了比较。在网状植入物组中，2周和3周时的组织学比较表明，ACaHW处理产生的骨结合能力与AH处理相似；在4周时，ACaHW的结合能力比AH更强。然而，在板状植入物组后期的测试中，这种差异并不明显。此处获得的结果表明，在植入早期，对Cp-Ti网状植入物进行ACaHW处理比AH处理具有更高的骨结合能力，从而为未来的临床应用提供了积极的参考。
