Nishimoto Yoshihiro, Nishimura Takashi, Yasuda Makoto
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan).
Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan).
Chemistry. 2015 Dec 7;21(50):18301-8. doi: 10.1002/chem.201503414. Epub 2015 Oct 30.
Herein, a coupling reaction of enol ethers with silyl ketene imines in the presence of catalytic amounts of InBr3 and Me3 SiBr is described. Kinetic studies have revealed that an indium catalyst and Me3 SiBr accelerated the coupling process and the regeneration of the catalyst, respectively. Various types of enol ethers and silyl ketene imines are applicable. In addition, a formal synthesis of verapamil was achieved by using this novel coupling reaction.
在此，描述了在催化量的三溴化铟和三甲基硅溴存在下烯醇醚与甲硅烷基烯酮亚胺的偶联反应。动力学研究表明，铟催化剂和三甲基硅溴分别加速了偶联过程和催化剂的再生。各种类型的烯醇醚和甲硅烷基烯酮亚胺均适用。此外，通过使用这种新型偶联反应实现了维拉帕米的形式合成。
