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Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study.

作者信息

Natarajan Pradeep, Kohli Puja, Baber Usman, Nguyen Khanh-Dung H, Sartori Samantha, Reilly Dermot F, Mehran Roxana, Muntendam Pieter, Fuster Valentin, Rader Daniel J, Kathiresan Sekar

出版信息

J Am Coll Cardiol. 2015 Nov 3;66(18):2053-2055. doi: 10.1016/j.jacc.2015.08.866.

DOI:10.1016/j.jacc.2015.08.866
PMID:26516010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4706229/
Abstract
摘要

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Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study.APOC3功能丧失突变与血脂及亚临床动脉粥样硬化的关联：多民族生物影像研究
J Am Coll Cardiol. 2015 Nov 3;66(18):2053-2055. doi: 10.1016/j.jacc.2015.08.866.
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本文引用的文献

1
Prevalence, impact, and predictive value of detecting subclinical coronary and carotid atherosclerosis in asymptomatic adults: the BioImage study.无症状成年人亚临床冠状动脉和颈动脉粥样硬化的患病率、影响和预测价值：BioImage 研究。
J Am Coll Cardiol. 2015 Mar 24;65(11):1065-74. doi: 10.1016/j.jacc.2015.01.017.
2
Loss-of-function mutations in APOC3 and risk of ischemic vascular disease.载脂蛋白 C3 基因失活突变与缺血性血管疾病风险
N Engl J Med. 2014 Jul 3;371(1):32-41. doi: 10.1056/NEJMoa1308027. Epub 2014 Jun 18.
3
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.载脂蛋白 C3 功能丧失突变与甘油三酯和冠心病。
N Engl J Med. 2014 Jul 3;371(1):22-31. doi: 10.1056/NEJMoa1307095. Epub 2014 Jun 18.
4
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.低频和罕见编码序列变异与 56000 名白人和黑人的血脂和冠心病的关联。
Am J Hum Genet. 2014 Feb 6;94(2):223-32. doi: 10.1016/j.ajhg.2014.01.009.
5
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.人类载脂蛋白C3（APOC3）的无效突变可带来良好的血脂谱并具有明显的心脏保护作用。
Science. 2008 Dec 12;322(5908):1702-5. doi: 10.1126/science.1161524.